Which tick-borne disease is characterized by a rash and flu-like symptoms?

Lyme disease is characterized by a distinctive rash often referred to as erythema migrans, which typically appears as a "bull's-eye" pattern. This early stage of the disease also presents with flu-like symptoms such as fever, fatigue, headache, and muscle or joint aches. These symptoms can develop within days to weeks after being bitten by an infected tick, making early recognition and treatment crucial.

In contrast, Rocky Mountain spotted fever also has flu-like symptoms but is notably associated with different types of rashes and more severe complications if not treated promptly. Human ehrlichiosis may present with similar flu-like symptoms, but it does not commonly include the characteristic rash associated with Lyme disease. The "Father of all fevers" is not an established tick-borne disease and does not relate to the symptoms or presentations typical of Lyme disease. Thus, the defining combination of a rash along with flu-like symptoms makes Lyme disease the correct response to the question.